diff --git a/tests/docker/dockerfiles/debian-mips64el-cross.docker b/tests/docker/dockerfiles/debian-mips64el-cross.docker
index 2862785692..bfa96cb507 100644
--- a/tests/docker/dockerfiles/debian-mips64el-cross.docker
+++ b/tests/docker/dockerfiles/debian-mips64el-cross.docker
@@ -1,10 +1,10 @@
 # THIS FILE WAS AUTO-GENERATED
 #
-#  $ lcitool dockerfile --layers all --cross-arch mips64el debian-11 qemu
+#  $ lcitool dockerfile --layers all --cross-arch mips64el debian-12 qemu
 #
 # https://gitlab.com/libvirt/libvirt-ci
 
-FROM docker.io/library/debian:11-slim
+FROM docker.io/library/debian:12-slim
 
 RUN export DEBIAN_FRONTEND=noninteractive && \
     apt-get update && \
@@ -48,16 +48,15 @@ RUN export DEBIAN_FRONTEND=noninteractive && \
                       python3-opencv \
                       python3-pillow \
                       python3-pip \
-                      python3-setuptools \
                       python3-sphinx \
                       python3-sphinx-rtd-theme \
                       python3-venv \
-                      python3-wheel \
                       python3-yaml \
                       rpm2cpio \
                       sed \
                       socat \
                       sparse \
+                      swtpm \
                       tar \
                       tesseract-ocr \
                       tesseract-ocr-eng \
@@ -69,8 +68,6 @@ RUN export DEBIAN_FRONTEND=noninteractive && \
     dpkg-reconfigure locales && \
     rm -f /usr/lib*/python3*/EXTERNALLY-MANAGED
 
-RUN /usr/bin/pip3 install tomli
-
 ENV CCACHE_WRAPPERSDIR "/usr/libexec/ccache-wrappers"
 ENV LANG "en_US.UTF-8"
 ENV MAKE "/usr/bin/make"
@@ -97,17 +94,13 @@ RUN export DEBIAN_FRONTEND=noninteractive && \
                       libcmocka-dev:mips64el \
                       libcurl4-gnutls-dev:mips64el \
                       libdaxctl-dev:mips64el \
-                      libdrm-dev:mips64el \
-                      libepoxy-dev:mips64el \
                       libfdt-dev:mips64el \
                       libffi-dev:mips64el \
                       libfuse3-dev:mips64el \
-                      libgbm-dev:mips64el \
                       libgcrypt20-dev:mips64el \
                       libglib2.0-dev:mips64el \
                       libglusterfs-dev:mips64el \
                       libgnutls28-dev:mips64el \
-                      libgtk-3-dev:mips64el \
                       libibverbs-dev:mips64el \
                       libiscsi-dev:mips64el \
                       libjemalloc-dev:mips64el \
@@ -126,8 +119,6 @@ RUN export DEBIAN_FRONTEND=noninteractive && \
                       librbd-dev:mips64el \
                       librdmacm-dev:mips64el \
                       libsasl2-dev:mips64el \
-                      libsdl2-dev:mips64el \
-                      libsdl2-image-dev:mips64el \
                       libseccomp-dev:mips64el \
                       libselinux1-dev:mips64el \
                       libslirp-dev:mips64el \
@@ -141,8 +132,7 @@ RUN export DEBIAN_FRONTEND=noninteractive && \
                       libusb-1.0-0-dev:mips64el \
                       libusbredirhost-dev:mips64el \
                       libvdeplug-dev:mips64el \
-                      libvirglrenderer-dev:mips64el \
-                      libvte-2.91-dev:mips64el \
+                      libxdp-dev:mips64el \
                       libzstd-dev:mips64el \
                       nettle-dev:mips64el \
                       systemtap-sdt-dev:mips64el \
diff --git a/tests/lcitool/mappings.yml b/tests/lcitool/mappings.yml
index 03b974ad02..0ab3a89013 100644
--- a/tests/lcitool/mappings.yml
+++ b/tests/lcitool/mappings.yml
@@ -2,6 +2,20 @@ mappings:
   flake8:
     OpenSUSELeap15:
 
+  # Due to https://bugs.debian.org/cgi-bin/bugreport.cgi?bug=1081535 we
+  # have to disable all packages that depend on libgl1-mesa-dri:mips64el
+  gtk3:
+    mips64el-deb:
+
+  libdrm:
+    mips64el-deb:
+
+  libepoxy:
+    mips64el-deb:
+
+  mesa-libgbm:
+    mips64el-deb:
+
   meson:
     OpenSUSELeap15:
 
@@ -60,6 +74,18 @@ mappings:
   python3-wheel:
     OpenSUSELeap15: python311-pip
 
+  sdl2:
+    mips64el-deb:
+
+  sdl2-image:
+    mips64el-deb:
+
+  virglrenderer:
+    mips64el-deb:
+
+  vte:
+    mips64el-deb:
+
 pypi_mappings:
   # Request more recent version
   meson:
diff --git a/tests/lcitool/refresh b/tests/lcitool/refresh
index c60490a7fa..35c5266381 100755
--- a/tests/lcitool/refresh
+++ b/tests/lcitool/refresh
@@ -166,7 +166,7 @@ try:
                                             "x86_64-linux-user,"
                                             "i386-softmmu,i386-linux-user"))
 
-    generate_dockerfile("debian-mips64el-cross", "debian-11",
+    generate_dockerfile("debian-mips64el-cross", "debian-12",
                         cross="mips64el",
                         trailer=cross_build("mips64el-linux-gnuabi64-",
                                             "mips64el-softmmu,mips64el-linux-user"))
