diff --git a/tcg/s390x/tcg-target-con-set.h b/tcg/s390x/tcg-target-con-set.h
index 426dd92e51..00ba727b70 100644
--- a/tcg/s390x/tcg-target-con-set.h
+++ b/tcg/s390x/tcg-target-con-set.h
@@ -29,8 +29,8 @@ C_O1_I2(v, v, v)
 C_O1_I3(v, v, v, v)
 C_O1_I4(r, r, ri, r, 0)
 C_O1_I4(r, r, ri, rI, 0)
-C_O2_I2(b, a, 0, r)
-C_O2_I3(b, a, 0, 1, r)
+C_O2_I2(o, m, 0, r)
+C_O2_I3(o, m, 0, 1, r)
 C_O2_I4(r, r, 0, 1, rA, r)
 C_O2_I4(r, r, 0, 1, ri, r)
 C_O2_I4(r, r, 0, 1, r, r)
diff --git a/tcg/s390x/tcg-target-con-str.h b/tcg/s390x/tcg-target-con-str.h
index 8bb0358ae5..76446aecae 100644
--- a/tcg/s390x/tcg-target-con-str.h
+++ b/tcg/s390x/tcg-target-con-str.h
@@ -11,13 +11,7 @@
 REGS('r', ALL_GENERAL_REGS)
 REGS('L', ALL_GENERAL_REGS & ~SOFTMMU_RESERVE_REGS)
 REGS('v', ALL_VECTOR_REGS)
-/*
- * A (single) even/odd pair for division.
- * TODO: Add something to the register allocator to allow
- * this kind of regno+1 pairing to be done more generally.
- */
-REGS('a', 1u << TCG_REG_R2)
-REGS('b', 1u << TCG_REG_R3)
+REGS('o', 0xaaaa) /* odd numbered general regs */
 
 /*
  * Define constraint letters for constants:
diff --git a/tcg/s390x/tcg-target.c.inc b/tcg/s390x/tcg-target.c.inc
index 33becd7694..47aaba7667 100644
--- a/tcg/s390x/tcg-target.c.inc
+++ b/tcg/s390x/tcg-target.c.inc
@@ -2258,10 +2258,18 @@ static inline void tcg_out_op(TCGContext *s, TCGOpcode opc,
         break;
 
     case INDEX_op_div2_i32:
-        tcg_out_insn(s, RR, DR, TCG_REG_R2, args[4]);
+        tcg_debug_assert(args[0] == args[2]);
+        tcg_debug_assert(args[1] == args[3]);
+        tcg_debug_assert((args[1] & 1) == 0);
+        tcg_debug_assert(args[0] == args[1] + 1);
+        tcg_out_insn(s, RR, DR, args[1], args[4]);
         break;
     case INDEX_op_divu2_i32:
-        tcg_out_insn(s, RRE, DLR, TCG_REG_R2, args[4]);
+        tcg_debug_assert(args[0] == args[2]);
+        tcg_debug_assert(args[1] == args[3]);
+        tcg_debug_assert((args[1] & 1) == 0);
+        tcg_debug_assert(args[0] == args[1] + 1);
+        tcg_out_insn(s, RRE, DLR, args[1], args[4]);
         break;
 
     case INDEX_op_shl_i32:
@@ -2515,17 +2523,30 @@ static inline void tcg_out_op(TCGContext *s, TCGOpcode opc,
         break;
 
     case INDEX_op_div2_i64:
-        /* ??? We get an unnecessary sign-extension of the dividend
-           into R3 with this definition, but as we do in fact always
-           produce both quotient and remainder using INDEX_op_div_i64
-           instead requires jumping through even more hoops.  */
-        tcg_out_insn(s, RRE, DSGR, TCG_REG_R2, args[4]);
+        /*
+         * ??? We get an unnecessary sign-extension of the dividend
+         * into op0 with this definition, but as we do in fact always
+         * produce both quotient and remainder using INDEX_op_div_i64
+         * instead requires jumping through even more hoops.
+         */
+        tcg_debug_assert(args[0] == args[2]);
+        tcg_debug_assert(args[1] == args[3]);
+        tcg_debug_assert((args[1] & 1) == 0);
+        tcg_debug_assert(args[0] == args[1] + 1);
+        tcg_out_insn(s, RRE, DSGR, args[1], args[4]);
         break;
     case INDEX_op_divu2_i64:
-        tcg_out_insn(s, RRE, DLGR, TCG_REG_R2, args[4]);
+        tcg_debug_assert(args[0] == args[2]);
+        tcg_debug_assert(args[1] == args[3]);
+        tcg_debug_assert((args[1] & 1) == 0);
+        tcg_debug_assert(args[0] == args[1] + 1);
+        tcg_out_insn(s, RRE, DLGR, args[1], args[4]);
         break;
     case INDEX_op_mulu2_i64:
-        tcg_out_insn(s, RRE, MLGR, TCG_REG_R2, args[3]);
+        tcg_debug_assert(args[0] == args[2]);
+        tcg_debug_assert((args[1] & 1) == 0);
+        tcg_debug_assert(args[0] == args[1] + 1);
+        tcg_out_insn(s, RRE, MLGR, args[1], args[3]);
         break;
 
     case INDEX_op_shl_i64:
@@ -3220,10 +3241,10 @@ static TCGConstraintSetIndex tcg_target_op_def(TCGOpcode op)
     case INDEX_op_div2_i64:
     case INDEX_op_divu2_i32:
     case INDEX_op_divu2_i64:
-        return C_O2_I3(b, a, 0, 1, r);
+        return C_O2_I3(o, m, 0, 1, r);
 
     case INDEX_op_mulu2_i64:
-        return C_O2_I2(b, a, 0, r);
+        return C_O2_I2(o, m, 0, r);
 
     case INDEX_op_add2_i32:
     case INDEX_op_sub2_i32:
